Technology

Metabolite profiling, now often called “metabolomics”, was first used successfully over 30 years ago for selected diagnostic applications. Metabolite profiling, now based on a significantly wider coverage of metabolic analytes, has been recently rediscovered as the tool of choice for a wide range of high value, precise and fast diagnostic applications as well as for discovery in the pharmaceutical and nutritional fields. Metabolite profiling is truely “taking off”. Broad metabolic coverage, the possibility to discover novel metabolic markers as well as the potential to monitor highly complex metabolic networks has been made possible by breakthroughs in modern analytical technologies. Progress has been driven by quantum leaps in computing and bioinformatics, embracing data validation, data processing, data clustering and data integration. Bioinformatics allows the reliable interpretation of complex metabolic patterns and novel markers can be identified fast and with high precision. Recent technology developments also enable metabolite profiling in exceptionally high throughput without loss of precision and reliability – if applied with care and expertise.

State of the art metabolite profiling allows a multitude of applications in plant biotechnology, nutrition research, supports all steps of drug development and is a key technology for medical diagnostics and marker development.

Investigating the highly complex network of metabolism in humans, plant and micro-organisms opens the door to the 4th dimension, the true functional level, of life. It adds a wealth of important and mission critical information, facilitating the creation of novel business value and speeding up research and development processes. However, the complexity of metabolism is a challenge which has to be mastered to obtain the full benefit. Many of the technical systems and processes required for complex metabolite profiling have been pioneered by metanomics GmbH – founding its international acclaim.

Metanomics Health offers a range of applications from its analytical toolkit, providing approaches from both schools of thought which are currently being used in metabolomics research: broad unbiased metabolite profiling and targeted profiling platforms.
While the broad profiling platform yields the largest possible range of detectable small molecules (< 1.5 kDa), the targeted platforms zoom in on more specific polarity windows with enhanced specificity and sensitivity to support hypothesis-driven study approaches. Our highly automated analytical discovery platform is designed to handle multiple projects in parallel and to run in high-throughput mode using a variety of different MS-based technologies (e.g. GC-MS, GC-X-GC, UPLC-MS/MS and SPE-LC-MS/MS, LC-TOF, LC-FTICR-MS).

The metabolomics platform available to Metanomics Health is based on
four distinct areas of expertise:

Sample Preparation

The sample preparation process is mostly automated and applicable to a multitude of matrices: body fluids (plasma, serum, CSF, urine etc.), cell cultures and tissue material from a wide range of species.

Metabolite Profiling Platforms

The GC-MS and LC-MS/MS systems in operation for metabolite profiling are of the most sensitive and powerful metabolomics technologies available to date, with more than 75 MS instruments on the platform. Results are highly robust and reproducible.



For more information: Metabolite Profiling Platforms

Bioinformatics & Systems Analysis

The bioinformatics tools, partly developed in house, allow highly sophisticated process control, data validation, data integraton, data mining and data visualisation.


For more information: Bioinformatics & Systems Analysis

Biomedical Data Interpretation

A dedicated and experienced team of experts at PhD level manages the
state-of-the-art transformation from statistically evaluated data sets to biological information and medical knowledge along metabolic pathways. Therapeutic area experts are assigned as project managers to each project and thus guarantee successful set-up, initiation, conduct and conclusion with actionable ultimate results




Please contact us for further information regarding your specific study request.