Services

Metanomics Health is looking for strategic collaborations to apply metabolite profiling and data analysis to support drug development, diagnostics and nutrition research.

Metabolite profiling is defined as the parallel analysis of multiple endogenous and xenobiotic metabolites in body fluids, tissues, or in-vitro cell cultures. These small molecules (<1.5 kDa) most closely reflect the physiological status of a biological system and are highly responsive to both genetic and environmental factors. The resulting characteristic metabolite fingerprints can be used as biomarkers to characterize the (patho-) physiological condition of an organism.

They may indicate the underlying mechanisms of disease or determine responses to drugs, nutritional intervention or toxic effects. In addition, metabolite markers have proven to be translatable across species based on highly conserved biochemical processes.


Technology Leadership

Metanomics Health combines state-of-the-art metabolite profiling with innovative bioinformatics and data mining systems to enable the discovery and validation of both, simple and complex metabolomic biomarkers.



Metanomics Health provides:

• The largest metabolite profiling platform globally, with over 75 GC-MS and LCMS/MS instruments
• Widest possible metabolite coverage via the unique combination of unbiased and targeted platforms including:
  • Amino acids, nucleobases, lipids, carbohydrates, vitamins and co-factors
  • Low abundance catecholamines and steroid hormones
  • Eicosanoids
  • Highly-polar energy metabolites and their phosphorylated derivatives
  • Simple and complex lipid profiles (lipidomics)

  
  

• Superior sensitivity, reproducibility and reliability of the largely automated high throughput platform
• Rigorous process control and data validation across the entire technology platform
• Unique toxicology mechanism of action classification and prediction through its proprietary database, MetaMap®Tox
• Proprietary software, knowledge base and data integration systems translate analytical data into dynamic pathway visualizations
• Excellence in the interpretation of metabolic patterns and systems correlation analysis of complex gene function relationships

Supporting Decision Making in Healthcare Research

Metanomics Health enables its pharma and biotech clients by:

• Increasing mechanistic understanding of drug and adverse effects as well as providing insights into underlying pathways



• Improving efficiency of clinical programs while reducing attrition through:
• Pre-selection of clinical candidates using Metanomics Health’s toxicology database (MetaMap®Tox)
• Assessment of intervention using the Metanomics Health data mining and interpretation platforms
• Identification and validation of biomarkers for efficacy and disease progression
• Identification of response markers for patient stratification







Please view the various Applications of our Metabolite Profiling Services and
contact us for further information regarding your specific study request to see how we can support your research!