Please contact us for further information on MetaMap®Tox and a quotation for your specific toxicology study request.

 

Mode of Toxicity Studies

MetaMap®Tox - Metabolite Profiling in Toxicology:
Early Safety Enablement in Pharmaceutical R&D


What is MetaMap®Tox?

  • A database of specific metabolomic patterns from rat plasma following treatment intervention
  • Robust and reproducible patterns for different tox modes of action (MoA)
  • To-date > 100 specific metabolite patterns validated for Tox-MoA



Please click on this video file to see a brief introduction to MetaMap®Tox in 2.20min




Please click on this video file to see a comprehensive webinar presentation in 44.40min
"Safer Drugs - Save Money: BASF subsidiary Metanomics Health launches MetaMap®Tox - a validated next-generation in vivo tool for early and systemic drug safety testing"





MetaMapTox


MetaMap®Tox – What do you get?

  • Compound-specific metabolomic patterns
  • Identification of critical tox MoA/target organs
  • Comparison with reference compounds
  • Expert assessment of underlying mechanisms



MetaMap®Tox – Successful External Validation
of MetaMap®Tox Utility for Safety Enablement

A novel technology for early safety enablement successfully evaluated by DSEC (The Drug Safety Executive Council )

The DSEC confirms value & utility of applying MetaMap®Tox complementary to a 28-day GLP standard tox study in the context use of:

  • a. Assessment of Mechanism of Action
    In particular assessment of mechanism of toxicity/adverse reaction,
    e.g. in case of arbitrary results from short term toxicological studies
  • b. Minimization of Toxicity / Adverse Reactions
    - Indicating/predicting systemic toxicity/adverse reactions (including idiosyncratic toxicities)
    - Detecting/monitoring onset/reversibility to toxicity/adverse reactions
  • c. Final Lead Selection
    MetaMap®Tox provides a detailed and systemic answer to compound performance on safety issues




MetaMap®Tox – Value Contribution in NCE Development
MetaMap®Tox application in pre-clinical safety assessment
MTXH_Website_MMTox_Bild1_20120619_680px


MetaMap®Tox – Safety Enablement Product Offers
Enabling safety in early pharmaceutical development
MTXH_Website_MMTox_Bild2_20120619_680px


MetaMap®Tox – Safety Enablement Product Offers
Established and Validated Toxicological Modes of Action (MoAs)
MTXH_Website_MMTox_Bild3_20120619_680px

Please contact us for further information regarding MetaMap®Tox and your specific study request.


Back to Applications Overview

Further Reading on MetaMap®Tox

  • W. B. Mattes, H. G. Kamp, E. Fabian, M. Herold, G. Krennrich, R. Looser,
    W. Mellert, A. Prokoudine, V. Strauss, B. van Ravenzwaay, T. Walk, H. Naraoka, K. Omura, I. Schuppe-Koistinen, S. Nadanaciva, E. D. Bush, N. Moeller,
    P. Ruiz-Noppinger and S. P. Piccoli
    (2013) Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling
    BioMed Research International Volume 2013 (2013), Article ID 202497,
    12 pages
    Link to publication
  • H. Kamp, V. Strauss, J. Wiemer, E. Leibold, T. Walk, W. Mellert, R. Looser, A. Prokoudine, E. Fabian, G. Krennrich, M. Herold, B. van Ravenzwaay
    (2012) Reproducibility and robustness of metabolome analysis in rat plasma of 28-day repeated dose toxicity studies
    Toxicology Letters Volume 215, Issue 2, 30 November 2012, Pages 143–149
    Link to Elsevier publication
  • Kamp H, Fabian E, Groeters S, Herold M, Krennrich G, Looser R, Mattes W, Mellert W, Prokoudine A, Ruiz-Noppinger P, Strauss V, Walk T, Wiemer J, van Ravenzwaay B.
    (2012) Application of in vivo metabolomics to preclinical/toxicological studies: case study on phenytoin-induced systemic toxicity
    Bioanalysis 2012 Sep;4(18): Pages 2291-2301. doi: 10.4155/bio.12.214.
    Link to PubMed.gov
  • V. Strauss, W. Mellert, Jan Wiemer, E. Leibold, Hennicke Kamp, Tilmann Walk, Ralf Looser, Alexandre Prokoudine, E. Fabian, G. Krennrich, Michael Herold, Bennard van Ravenzwaay
    (2012) Increased toxicity when fibrates and statins are administered in combination – A metabolomics approach with rats
    Toxicology Letters Volume 211 (2012), Issue 2, Pages 91-210
    Link to Elsevier publication
  • Bennard van Ravenzwaay, Herold M, Kamp H, Kapp MD, Fabian E, Looser R, Krennrich G, Mellert W, Prokoudine A, Strauss V, Walk T, Wiemer J
    (2012) Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-From QSAR to QBAR
    Mutation Research
    Link to PubMed.gov
  • Gerd U. Balcke, S.N. Kolle, Hennicke Kamp, Biancs Bethan, Ralf Looser, S. Wagner, Robert Landsiedel, Bennard van Ravenzwaay
    (2011) Linking energy metabolism to dysfunctions in mitochondrial respiration – A metabolomics in vitro approach
    Toxicology Letters
    Link to Elsevier online publication

  • MetaMap®Tox Poster: Bennard van Ravenzwaay et al. (SOT 2011) Impact of nutrition on the plasma metabolome in rats
    Link to Poster Download [PDF, 50 KB]

  • MetaMap®Tox Poster: Bennard van Ravenzwaay et al. (SOT 2011) Reproducibility of metabolomics performed in plasma samples of 28 day rat systemic toxicity studies
    Link to Poster Download [PDF, 30 KB]

  • Bennard van Ravenzwaay, G. Coelho-Palermo Cunha, V. Strauss, Jan Wiemer, E. Leibold, Hennicke Kamp, Tilmann Walk, W. Mellert, Ralf Looser, Alexandre Prokoudine, E. Fabian, G. Krennrich, Michael Herold
    (2010) The individual and combined metabolite profiles (metabolomics) of
    dibutylphthalate and di(2-ethylhexyl)phthalate following a 28-day dietary exposure in rats
    Toxicology Letters
    Link to Elsevier publication
  • V. Strauss, Jan Wiemer, E. Leibold, Hennicke Kamp, Tilmann Walk,W. Mellert,
    Ralf Looser, Alexandre Prokoudine, E. Fabian, G. Krennrich, Michael Herold, Bennard van Ravenzwaay
    (2009) Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies
    Toxicology Letters
    Link to Elsevier publication

  • MetaMap®Tox Poster: Bennard van Ravenzwaay et al. (Innoforum 2008) Statistical Tools for Enhancing Metabolomic Profiling
    Link to Poster Download [PDF, 220 KB]

  • Bennard van Ravenzwaay, G. Coelho-Palermo Cunha, E. Leibold,
    Ralf Looser , W. Mellert , Alexandre Prokoudine , Tilmann Walk, Jan Wiemer
    (2007) The use of metabolomics for the discovery of new biomarkers of effect
    Toxicology Letters
    Link to Elsevier publication