Applications

Metanomics Health applies state-of-the-art comprehensive metabolite profiling (metabolomics) with in-depth biomedical data interpretation utilizing innovative bioinformatics and data mining systems. Focus is on biomarker identification and validation across various applications providing healthcare industry partners with actionable insight along research and development programs.

Fields of application are:

• Mechanism of Action Studies
  The identification of metabolic biomarkers for mechanistic understanding of drug effects combined with knowledge of the underlying biological pathways and regulatory networks supports and accelerates decision making in all steps of drug discovery and development.
• Mode of Toxicity Studies
  Improved differentiation and understanding of drug mode-of-toxicity and side-effects accelerates lead optimization and supports decision-making during early drug development.
  See MetaMapTox Application for more details .
  
• Translational and Clinical Biomarker Development (e.g. PK/PD, Patient Stratification, Efficacy and Safety Markers)
  Information on efficacy or responder group differentiation enables focussed and economized clinical studies for a faster drug development (PK/PD biomarkers, disease and disease progression biomarkers).
  
• Nutrition, nutrigenomics and consumer products R&D
  Physiological understanding of the impact of specific nutrients on health allows the development of tailor-made nutrition for prevention of disease.

• Diagnostic Development
  Metabolic biomarkers for the early diagnosis of diseases facilitates the development of diagnostic tools for disease prevention and treatment.
• Cell Culture & Bioprocess Optimization

Optimization of Bioprocess Conditions:• Comprehensive analysis of cellular function
• Understand and optimize biological processes
• Discover potential bottlenecks and feedback inhibition to optimize yields

Optimization of Media Formulations:• Identify critical media components
• Monitor lot-to-lot variation
• Determine shelf-life of media
• Develop defined media, serum-free media
Optimization of Cell Lines & Strains:• Identify targets for strain improvement
• Characterize mutant strains
• Elucidate function of orphan genes


Please check our Metabolite Profiling Services and
contact us for further information regarding your specific study request to see how we can support your research!